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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
38.79
Human Site:
S352
Identified Species:
60.95
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
N
A
Chimpanzee
Pan troglodytes
XP_514546
950
108522
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
N
A
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
N
A
Dog
Lupus familis
XP_534324
950
108331
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
G
A
Rat
Rattus norvegicus
NP_001102066
561
63850
K36
K
E
K
R
K
R
M
K
R
D
Q
P
A
F
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
G
A
Chicken
Gallus gallus
Q5ZIP4
949
108524
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
G
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
F348
C
F
F
V
G
N
D
F
L
P
H
L
P
S
L
Honey Bee
Apis mellifera
XP_392371
860
99367
F320
L
Q
M
P
N
L
P
F
K
Y
D
F
E
R
V
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
S351
D
F
L
P
H
L
P
S
L
E
I
R
E
G
A
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
S342
D
F
L
P
H
L
P
S
L
E
I
R
E
G
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
T353
D
F
L
P
H
M
P
T
L
E
I
R
E
G
A
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
C340
D
F
L
P
H
L
P
C
L
D
V
R
E
N
S
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
A358
D
F
L
P
H
L
P
A
L
E
I
R
E
N
G
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
100
100
93.3
N.A.
93.3
0
N.A.
93.3
93.3
N.A.
N.A.
N.A.
13.3
26.6
93.3
93.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
93.3
93.3
N.A.
N.A.
N.A.
20
40
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
80
73.3
86.6
P-Site Similarity:
N.A.
N.A.
N.A.
93.3
93.3
93.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
67
% A
% Cys:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
80
0
0
0
0
0
7
0
0
14
7
0
0
0
0
% D
% Glu:
0
7
0
0
0
0
0
0
0
74
0
0
87
0
0
% E
% Phe:
0
87
7
0
0
0
0
14
0
0
0
7
0
7
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
0
47
7
% G
% His:
0
0
0
0
80
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
74
0
0
0
0
% I
% Lys:
7
0
7
0
7
0
0
7
7
0
0
0
0
0
0
% K
% Leu:
7
0
80
0
0
80
0
0
87
0
0
7
0
0
7
% L
% Met:
0
0
7
0
0
7
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
7
0
0
0
0
0
0
0
34
0
% N
% Pro:
0
0
0
87
0
0
87
0
0
7
0
7
7
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
7
0
7
0
0
7
0
0
80
0
7
0
% R
% Ser:
0
0
0
0
0
0
0
60
0
0
0
0
0
7
7
% S
% Thr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% T
% Val:
0
0
0
7
0
0
0
0
0
0
7
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _